• ALK fusion positive NSCLC is clinically actionable because i

  2024-05-17

  

  ALK fusion-positive NSCLC is clinically actionable because it can be targeted by several FDA-approved drugs, including the first generation TKI crizotinib, which is a dual inhibitor to MET and ALK [15], and the second generation inhibitors, alectinib and ceritinib, both of which are highly-selective

• br Acknowledgements Dr Paul J Gasser is supported by the

  2024-05-17

  

  Acknowledgements Dr. Paul J. Gasser is supported by the National Institutes of Health (grant number R01DA032895), and the Charles E. Kubly Mental Health Research Center. Dr. Christopher A. Lowry is supported by the National Institutes of Health (grant number R21 MH116263), the Department of the N

• br Introduction Cell motility is fundamentally important in

  2024-05-17

  

  Introduction Cell motility is fundamentally important in morphogenesis, wound healing, and the immune response. One of the best-studied basic types of cell movement is lamellipodial motility [1, 2], characterized by a thin (∼0.1–0.2 μm), broad (∼10–40 μm) motile appendage containing a dynamic Paz

• br Methods br Results From a study population of patients

  2024-05-17

  

  Methods Results From a study population of 7069 patients, a total of 149 falls were reported during the study Calcipotriol for an incidence rate (IR) of 5.2 falls per 1000 patient-days (PD), 95% confidence interval (CI) 4.4/1000 PD–6.1/1000 PD. The incidence rate ratio (IRR) for patients in th

• Whereas more research is needed to identify the precise

  2024-05-17

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Liproxstatin-1 that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed the

• Whereas more research is needed to identify the precise

  2024-05-17

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Cariprazine synthesis that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely rever

• Although experiments on animals and cells indicate that anti

  2024-05-17

  

  Although experiments on animals and cells indicate that antioxidant and free radical scavenging agents have protective effects against brain damage, the results of preclinical trials are not as encouraging. Edaravone is a type of free radical scavenging drug that was first used as a neuroprotective

• br Author contributions br Conflict

  2024-05-17

  

  Author contributions Conflict of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81502276), Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province (A2017013), the Natural Science Foundation o

• br Autophagy inducers Macroautophagy is often seen

  2024-05-16

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of KB SRC 4 and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensitivity of can

• Introduction The first use of the term autophagy by

  2024-05-16

  

  Introduction The first use of the term “autophagy” by a French physiologist, M. Anselmier, in a short article describing the effects of fasting in mice published in 1859, took place almost a century before Christian De Duve described it from a mechanistic point of view in a symposium on lysosomes i

• br Conclusion In summary screening a small compound library

  2024-05-16

  

  Conclusion In summary, screening a small compound library based on the 3-aminopyridin-2-one motif in a target-blind manner against a 26-kinase panel, representative of the kinome, identified hits that possess good activity and excellent ligand efficiency against MPS1, Aurora A and Aurora B. The b

• MADS box proteins are combinatorial transcription factors in

  2024-05-16

  

  MADS box proteins are combinatorial transcription factors in that they often derive their regulatory specificity from other DNA binding or accessory factors. In many cases, the cofactor with which MADS box proteins interact specifies which genes are regulated, when they are regulated and if these ge

• thrombopoietin receptor agonist Physical and chemical preser

  2024-05-16

  

  Physical and chemical preservatives such as ultraviolet and ɣ-rays irradiation, sulphur and aluminium phosphide fumigation, etc, have been introduced to inhibit the growth of fungi. Nevertheless, due to the potential decomposition reactions and residues, as well as their own potential toxicity, and

• Introduction Cardiovascular disease is the

  2024-05-16

  

  Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with Esomeprazole Sodium (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardiov

• Another important finding of our study is the observation

  2024-05-16

  

  Another important finding of our study is the observation that high glucose per se does not affect TER in mature HREC monolayers; but at the same time it does upregulate ICAM-1 directly and activates HRECs to leukocyte adhesion. This would imply that high glucose affects TER in mature HREC monolayer

16336 records 150/1090 page Previous Next First page 上5页 146147148149150 下5页 Last page